MSSSTEST(1)

📦 version 3.0, in debian bookworm, debian trixie, ubuntu jammy, ubuntu noble, ubuntu resolute, ubuntu stonking

💖 MSSSTEST(1) — the girlies' guide to disease-score normalisation 💖

okay so bestie, welcome to the mssstest page from the General Commands Manual, section 1 🎀. Sit down, grab a strawberry 🍓, and let's get into it.

✨ NAME ✨

mssstest — normalisation of disease scores, originally developed for the EDSS for Multiple Sclerosis 🧠💜

(yes, the original header literally says "Normalisationo" and honestly? iconic typo, we're keeping the energy, not the typo. it's normalisation. periodt.)

🌸 SYNOPSIS 🌸

mssstest

that's it. that's the whole synopsis. no flags, no args, no nothing. she's lowkey a mystery 💅

🦋 DESCRIPTION 🦋

okay so picture this: you wanna know whether the genotype at some locus of interest affects the rate of progression of disease in people with Multiple Sclerosis (MS). main character research question, fr fr.

one approach would be to calculate the mean EDSS score in patients with each of the genotypes and test whether they're significantly different. sounds fine, right? wrong 🙈. that approach is inefficient if patients have their EDSS assessed at different durations of disease — because patients who have had MS longer typically have higher EDSS scores regardless of their genotype. the duration is out here doing its own thing and ruining the vibe check. but by adjusting for duration, a more powerful test can be developed. slay ✨

MSSStest is a program for implementing the method described in the article The Multiple Sclerosis Severity Score. R. Roxburgh S. Seaman et al. (2004), accepted for publication by Neurology. it calculates MSSS scores and uses these scores to test for differences between disease progression rates in different groups defined by genotype at some locus. no cap. 🔥

to use the program, first copy the table of disease scores to the current directory. you are expected to use the EDSS scores provided by the authors — that's the assignment, bestie, don't freelance it 👑

💅 OPTIONS 💅

the program does not accept options. it should, though. 😭 (the original really said that, I'm not even joking.)

the output goes to the files msss.out and indivmsss.out. two files. two icons. 🫶

🌈 SEE ALSO 🌈

👑 AUTHOR 👑

mssstest was written by Shaun Seaman and Richard Roxburgh <Richard@Roxburgh.net.nz>.

this manual page was written by Steffen Moeller <moeller@pzr.uni-rostock.de>, for the Debian project (but may be used by others). generous queen behaviour honestly 💖

⚠️ no options, no flags, no mercy. she just runs. mssstest. that's the whole thing. iykyk.

and that's the page, bestie!! 🎀 this version is from November 30, 2004, and it's the MSSSTEST(1) page from the General Commands Manual — go forth and normalise those scores, you absolute legend 💜🦋✨

📦 where this page comes from