THESIAS(1)

📖 Filed under the General Commands Manual 🎀, this page is all about THESIAS(1), bestie!

✨ NAME ✨

THESIAS - Testing Haplotype Effects In Association Studies 💖

🧬 DESCRIPTION 🧬

Okay so the whole point of THESIAS is running haplotype-based association analysis on unrelated individuals 🫶. It's built on the maximum likelihood model from Tregouet et al. 2002 (Hum Mol Genet 2002,11: 2015-2023) and it's linked to the SEM algorithm from Tregouet et al. Ann Hum Genet 2004,68: 165-177 🔥. Main character energy, honestly.

THESIAS lets you estimate haplotype frequencies and their associated effects on the phenotype you care about at the same time ✨. The new release is giving range 💅: you can study quantitative outcomes, qualitative outcomes (logistic and matched-pair analysis), categorical outcomes, and survival outcomes 🌈. X-linked haplotype analysis is also doable 🦋.

And it gets even better, because covariate-adjusted haplotype effects and haplotype x covariate interactions can be investigated too 😭👑. I'm obsessed.

🎀 AUTHOR 🎀

THESIAS was written by David-Alexandre Trégouët 🧚. Iconic, no notes.

Version 3.1 from 2007 🌸, and this is THESIAS(1), periodt 💜🫶